منابع مشابه
Sorting it out
The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alterna...
متن کاملSorting it out, without clathrin
Sorting it out, without clathrin lathrin-independent endocytosis is revealing itself at last. Intermediary organelles in this pathway have been difficult to identify, due in part to a dearth of markers and, until recently, difficulties in blocking the clathrin-dependent process. But now, has identified a set of endosomes that are uniquely C involved in clathrin-independent trafficking. Nichols'...
متن کاملSorting it out: Machine learning and fingerprints
Machine learning concepts can find applications in many domains. We describe here one such application to the problem of fingerprint verification. In biometric verification using fingerprints, one often has to handle large archives of fingerprint images. When verifying an individual fingerprint, it is important to have a fast method at hand that selects suitable candidate images out of a large ...
متن کاملSorting it All Out with Humans in the Loop
From an early age, we sort jellybeans with friends, placing watermelon flavor at the top of our list, and pushing licorice to the bottom. We contribute to larger-scale ranking operations when we rate a product in an online catalog. Given the prevalence of human-powered ranking in the digital realm, it is important to study the most effective user interfaces and algorithms for eliciting rankings...
متن کاملThe c - SMAC : sorting it all out ( or in )
T cells integrate and transduce the key signals necessary to mount an appropriate immune response. To do this, they rely on both secreted factors as well as physical cell– cell contact. Much attention has focused on the organization of proteins at the contact area between a T cell and an antigen-presenting cell, known as the immunological synapse. It has been shown in vitro that proteins segreg...
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ژورنال
عنوان ژورنال: The Iowa Review
سال: 1998
ISSN: 0021-065X,2330-0361
DOI: 10.17077/0021-065x.5060